Search results for "Basic Sciences"

showing 3 items of 3 documents

Impact of body weight, low energy diet and gastric bypass on drug bioavailability, cardiovascular risk factors and metabolic biomarkers: protocol for…

2018

IntroductionRoux-en-Y gastric bypass (GBP) is associated with changes in cardiometabolic risk factors and bioavailability of drugs, but whether these changes are induced by calorie restriction, the weight loss or surgery per se, remains uncertain. The COCKTAIL study was designed to disentangle the short-term (6 weeks) metabolic and pharmacokinetic effects of GBP and a very low energy diet (VLED) by inducing a similar weight loss in the two groups.Methods and analysisThis open, non-randomised, three-armed, single-centre study is performed at a tertiary care centre in Norway. It aims to compare the short-term (6 weeks) and long-term (2 years) effects of GBP and VLED on, first, bioavailability…

OncologyMale030226 pharmacology & pharmacylaw.inventionTertiary Care Centers0302 clinical medicineWeight losslawRisk FactorsProtocol1506Omeprazolemedia_commonClinical Trials as TopicClinical pharmacologyNorwayArea under the curveGeneral MedicineObesity MorbidPharmaceutical PreparationsCardiovascular DiseasescardiologyBody CompositionFemalemedicine.symptommedicine.drugDrugmedicine.medical_specialtymedia_common.quotation_subjectGastric Bypassbasic sciencesBiological Availability030209 endocrinology & metabolism03 medical and health sciencesPharmacokineticsInternal medicineWeight LossmedicineHumansRosuvastatinPharmacokinetics1723Caloric Restrictionbusiness.industryPharmacology and TherapeuticsBioavailabilityLinear Modelsclinical pharmacologybusinessBiomarkers
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Leisure-Time and Occupational Physical Activity Associates Differently with Epigenetic Aging

2021

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MaleAgingLeisure timeliikuntaEpigenesis Genetic0302 clinical medicineTwins DizygoticMedicineOrthopedics and Sports MedicineYoung adult315 Sport and fitness sciencesAge FactorsMETHYLATIONMiddle AgedDNA-metylaatioepigenetiikkaComputingMethodologies_DOCUMENTANDTEXTPROCESSINGFemaleSmoking statusSMOKINGfyysinen aktiivisuusAdultPhysical activityPhysical Therapy Sports Therapy and RehabilitationBIOLOGICAL AGINGYoung Adult03 medical and health sciencesLeisure ActivitiesSex FactorsHumansEpigeneticsExerciseOccupational HealthAgedModels GeneticBasic Sciencesbusiness.industrydNaMTwins Monozygotic030229 sport sciencesDNA MethylationTwin studyfyysinen kuormittavuusikääntyminentyön kuormittavuusbusinessLifestyle habitshuman activitiesQUANTITATIVE GENETICSDemography
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Endothelial GLP-1 (Glucagon-Like Peptide 1) Receptor Mediates Cardiovascular Protection by Liraglutide In Mice With Experimental Arterial Hypertension

2019

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0301 basic medicineMalemedicine.medical_specialtyhypertensionBlotting WesternInflammationBlood Pressure030204 cardiovascular system & hematologyangiotensin IImedicine.disease_causeGlucagon-Like Peptide-1 Receptor1005403 medical and health sciencesMice0302 clinical medicine10030Internal medicinemedicineoxidative stressAnimalsHypoglycemic AgentsReceptor10111Cells CulturedMice KnockoutliraglutideLiraglutidebusiness.industryBasic SciencesType 2 Diabetes MellitusEndothelial CellsAtherosclerosisGlucagon-like peptide-1Angiotensin II3. Good healthMice Inbred C57BLDisease Models Animal030104 developmental biologyEndocrinology10040inflammationComputingMethodologies_DOCUMENTANDTEXTPROCESSINGRNAmedicine.symptomCardiology and Cardiovascular Medicinebusiness10024Oxidative stressmedicine.drug
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